Dark Fire

Investigating the origins of Santa Claus, a cynical reporter comes to believe that his fiancee, whom he spurned for believing in Santa, may have been right, in a warm-hearted tale of Christmas wonder and love.

Were it not for the calculus, mathematicians would have no way to describe the acceleration of a motorcycle or the effect of gravity on thrown balls and distant planets, or to prove that a man could cross a room and eventually touch the opposite wall. Just how calculus makes these things possible and in doing so finds a correspondence between real numbers and the real world is the subject of this dazzling book by a writer of extraordinary clarity and stylistic brio. Even as he initiates us into the mysteries of real numbers, functions, and limits, Berlinski explores the furthest implications of his subject, revealing how the calculus reconciles the precision of numbers with the fluidity of the changing universe.

From Jonathan Weiner, Pulitzer Prize-winning author of The Beak of the Finch, comes His Brother’s Keeper — the story of a young entrepreneur who gambles on the risky science of gene therapy to try to save his brother’s life.

Stephen Heywood was twenty-nine years old when he learned that he was dying of ALS — Lou Gehrig’s disease. Almost overnight his older brother, Jamie, turned himself into a genetic engineer in a quixotic race to cure the incurable. His Brother’s Keeper is a powerful account of their story, as they travel together to the edge of medicine.

The book brings home for all of us the hopes and fears of the new biology. In this dramatic and suspenseful narrative, Jonathan Weiner gives us a remarkable portrait of science and medicine today. We learn about gene therapy, stem cells, brain vaccines, and other novel treatments for such nerve-death diseases as ALS, Alzheimer’s, and Parkinson’s — diseases that afflict millions, and touch the lives of many more.

It turns out that the author has a personal stake in the story as well. When he met the Heywood brothers, his own mother was dying of a rare nerve-death disease. The Heywoods’ gene therapist offered to try to save her, too.

“The Heywoods’ story taught me many things about the nature of healing in the new millennium,” Weiner writes. “They also taught me about what has not changed since the time of the ancients and may never change as long as there are human beings — about what Lucretius calls ‘the ever-living wound of love.’

“The Heywoods mean the whole story to me now: an allegory from the edge of medicine. A story to make us ask ourselves questions that we have to ask but do not want to ask. How much of life can we engineer? How much is permitted us?

“What would you do to save your brother’s life?”